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Neonatal cheiloplasty as the first surgery in patients with orofacial clefts, its benefits and possible risks
Kordačová, Karolína ; Velemínská, Jana (advisor) ; Hoffmannová, Eva (referee)
Neonatal cheiloplasty is the first plastic surgery performed in patients with orofacial clefts, usually carried out at the age of 1 to 8 days. A modified protocol for standard cheiloplasty, performed at the age of 3 to 6 months, is used. Neonatal cheiloplasty is currently a predominant method for lip surgery in cleft lip patients in the Czech Republic. Advantages of this method are better scar healing associated with better aesthetic results, reduced psychological and sociological pressure on the family and the infant, better quality of feeding and breastfeeding, and possibly reduced need of secondary repair. There is no documented direct negative consequence of the early timing. Nevertheless, possible risks can be associated with general anaesthesia at such low age, as it could have a negative effect on future IQ of the patient, and a possibility of reduced growth and development of jaws and impaired facial aesthetic outcomes. Further, compared to classical cheiloplasty, early surgery is more expensive and demands higher skills and experiences of the surgeon and the whole team performing the procedure. Main goals of this work were to evaluate the benefits and possible risks of neonatal cheiloplasty as the first surgery performed in patients with orofacial clefts using available studies on this...
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Analysis of embryotoxic effect of hydrocortisone using chick embryotoxicity screening test (CHEST).
Janíková, Michaela ; Peterka, Miroslav (advisor) ; Hovořáková, Mária (referee)
Cleft lip is one of the most common human birth deffects. Its etiopathogenesis is multifactorial and many aspects of its occurrence remain unknown in the fields of both genetics and teratology. One of the set of known negative external factors causing cleft lip is chemical hydrocortisone. Its effect on cell proliferation is highly heterogeneous and depends on attributes of a specific cell population. In this work we studied the cleft beak origin after the hydrocortisone treatment on the basis of Chick Embryotoxicity Screening Test (CHEST). Our main aim was to detect cell cycle changes in the chick frontonasal process after hydrocortisone injection via flow cytometry analysis. Hydrocortisone caused S phase arrest within a minor subpopulation of highly granular cells with specific cell cycle. This sensitive subpopulation was localized in the areas of previously defined proliferative centers within the frontonasal process using immunohistochemistry of frozen sections. Quantitative analysis of cells in these areas revealed significant decrease of M phase portion in the hydrocortisone treated samples in comparison with the control samples. The TUNEL staining of histological sections was used to determine the apoptotic rate in the frontonasal process. The comparison between the control and the...
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Possibilities of rehabilitation in children with cleft defects
Ješutová, Kateřina ; Černická, Barbara (advisor) ; Málková, Michaela (referee)
The cleft defects of orofacial complex belong among the most frequent congenital defects. These defects are affecting functions of orofacial complex and then complications of food intake, breathing, phonation and mimics can occur. On that ground the treatment needs complex care. The members of multidisciplinar team are plastic surgeon, orthodontist, paediatrician, geneticist, anaesthetist, anthropologist, phoniatrician, speech therapist and psychologist. The aim of the work is to describe physiotherapeutical techniques, methods or concepts, which can reduce, clear off or prevent disorders of orofacial complex functions since newborns. Currently it can support physiological motory development of children. The assimilation of physiotherapy into care complex could improve therapy for children with cleft defects. Powered by TCPDF (www.tcpdf.org)
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Analysis of interdisciplinary approach to children with orofacial clefts
Novotná, Kateřina ; Korandová, Zuzana (advisor) ; Klenková, Jiřina (referee)
The topic of this diploma thesis is an analysis of interdisciplinary approach to children with orofacial clefts. The first chapter deals with theoretical base and defines terminology - communication, communication disabilites. It also defines anatomy and physiology of nasal cavity and oral cavity. The second chapter relates to issues of orofacial clefts. It describes classification, etiology, symptomatology, prevention, aestetic and psychosocial impacts and orofacial cleft children care. The third chapter deals with occurence of communication disabilites of children with orofacial clefts. It focuses on the definition of palatholaly, velopharyngeal inadequacy and it describes various linguistic levels and speech therapy and intervention. The fourth chapter is empiric and it deals with analysis of interdisciplinary approach to children with orofacial clefts. In research processes there were used scientific literature analysis, anamnestic data analysis and available specialized materials analysis. Based on all of these materials six case studies were created. Main goal of this empiric chapter was to analyze interdisciplinary approach to children with orofacial clefts. Partial goals were to analyze whether information provided by experts and doctors to parents of newborn children with orofacial cleft...
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Neonatal cheiloplasty as the first surgery in patients with orofacial clefts, its benefits and possible risks
Kordačová, Karolína ; Velemínská, Jana (advisor) ; Hoffmannová, Eva (referee)
Neonatal cheiloplasty is the first plastic surgery performed in patients with orofacial clefts, usually carried out at the age of 1 to 8 days. A modified protocol for standard cheiloplasty, performed at the age of 3 to 6 months, is used. Neonatal cheiloplasty is currently a predominant method for lip surgery in cleft lip patients in the Czech Republic. Advantages of this method are better scar healing associated with better aesthetic results, reduced psychological and sociological pressure on the family and the infant, better quality of feeding and breastfeeding, and possibly reduced need of secondary repair. There is no documented direct negative consequence of the early timing. Nevertheless, possible risks can be associated with general anaesthesia at such low age, as it could have a negative effect on future IQ of the patient, and a possibility of reduced growth and development of jaws and impaired facial aesthetic outcomes. Further, compared to classical cheiloplasty, early surgery is more expensive and demands higher skills and experiences of the surgeon and the whole team performing the procedure. Main goals of this work were to evaluate the benefits and possible risks of neonatal cheiloplasty as the first surgery performed in patients with orofacial clefts using available studies on this...
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Analysis of embryotoxic effect of hydrocortisone using chick embryotoxicity screening test (CHEST).
Janíková, Michaela ; Peterka, Miroslav (advisor) ; Hovořáková, Mária (referee)
Cleft lip is one of the most common human birth deffects. Its etiopathogenesis is multifactorial and many aspects of its occurrence remain unknown in the fields of both genetics and teratology. One of the set of known negative external factors causing cleft lip is chemical hydrocortisone. Its effect on cell proliferation is highly heterogeneous and depends on attributes of a specific cell population. In this work we studied the cleft beak origin after the hydrocortisone treatment on the basis of Chick Embryotoxicity Screening Test (CHEST). Our main aim was to detect cell cycle changes in the chick frontonasal process after hydrocortisone injection via flow cytometry analysis. Hydrocortisone caused S phase arrest within a minor subpopulation of highly granular cells with specific cell cycle. This sensitive subpopulation was localized in the areas of previously defined proliferative centers within the frontonasal process using immunohistochemistry of frozen sections. Quantitative analysis of cells in these areas revealed significant decrease of M phase portion in the hydrocortisone treated samples in comparison with the control samples. The TUNEL staining of histological sections was used to determine the apoptotic rate in the frontonasal process. The comparison between the control and the...
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Possibilities of rehabilitation in children with cleft defects
Ješutová, Kateřina ; Černická, Barbara (advisor) ; Málková, Michaela (referee)
The cleft defects of orofacial complex belong among the most frequent congenital defects. These defects are affecting functions of orofacial complex and then complications of food intake, breathing, phonation and mimics can occur. On that ground the treatment needs complex care. The members of multidisciplinar team are plastic surgeon, orthodontist, paediatrician, geneticist, anaesthetist, anthropologist, phoniatrician, speech therapist and psychologist. The aim of the work is to describe physiotherapeutical techniques, methods or concepts, which can reduce, clear off or prevent disorders of orofacial complex functions since newborns. Currently it can support physiological motory development of children. The assimilation of physiotherapy into care complex could improve therapy for children with cleft defects. Powered by TCPDF (www.tcpdf.org)
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Health and social problems in children with facial cleft defects
SYROVÁ, Barbora
This dissertation is aimed at cleft deformities and in particular at the medical and social issues surrounding them. Its primary aim was to establish the complications which influence the quality of life of these children and their families, while the secondary aim was to ascertain, whether these complications have an effect on the psychosomatic development of the child. The aims of the baccalaureate dissertation were fulfilled. The research study thus reveals that the aforementioned complications can have an effect on the quality of life should they require intensive medical attention. Thanks to early lip and palate operations we are nowadays able to eliminate the consequences of this congenital developmental condition.
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